Manuel B. Garcia

Manuel B. Garcia serves as the Senior Director for Educational Technology and Digital Learning at FEU Institute of Technology, Manila, Philippines. Read More

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Can Generative AI Identify Which Reviewer Comments Require New Analyses?

Generative AI may help identify reviewer comments that appear to request new statistical or qualitative analyses. However, authors must distinguish actual analytical requirements from requests for clarification, assess whether additional analyses are justified, and avoid conducting unnecessary or misleading tests merely to satisfy generated revision plans.

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01 · The Question

Can AI Tell Which Reviewer Comments Require Additional Research Analysis?

You receive a major revision decision containing numerous reviewer comments. Some ask for clearer explanations of existing methods, while others suggest robustness checks, additional statistical models, subgroup comparisons, or further qualitative interpretation.

It is not immediately obvious which comments require new analytical work and which can be addressed by improving the manuscript's reporting.

For example, a reviewer may ask the authors to explain how missing data were handled. Another may request an additional model that accounts for classroom-level clustering. A third may suggest exploring differences between student groups.

Generative AI could help classify these comments and identify which ones may require new analyses. But a system might mistake a request for clarification as an instruction to conduct additional research, or recommend analyses that are statistically inappropriate.

Can AI help authors identify analytical revision requirements without making methodological decisions on their behalf?

02 · The Short Answer

AI Can Flag Potential Analysis Requests, but Authors Must Decide What Is Necessary

In Brief

Generative AI can help identify reviewer comments that appear to request new analyses, distinguish them from reporting or clarification tasks, and organize the resulting work. However, authors must independently determine whether an analysis is scientifically justified, feasible with the available data, and necessary to address the underlying reviewer concern.

Not every request for additional information requires reanalysis, and not every proposed analysis should be performed. Authors should evaluate the research design, statistical assumptions, data availability, and consequences for interpretation before proceeding. AI-generated classifications should be verified against the original reviewer comments and the editor's instructions.

03 · What You Need to Know

How to Distinguish Reviewer Requests for Clarification, Reanalysis, and New Research

Reviewer Comments Often Mix Reporting and Analytical Concerns

A reviewer may identify a legitimate concern without specifying exactly how it should be addressed.

For example, "Please explain whether missing observations could have influenced the findings" may invite clarification of an existing procedure, a sensitivity analysis, or a more cautious interpretation.

The appropriate response depends on what the authors originally did, what information is available, and how consequential the missing data may be.

Generative AI can help separate the different possibilities, but it should not automatically select the most elaborate response.

The purpose is to address the scientific concern adequately, not to maximize the number of new analyses.

What Types of Reviewer Comments May Require New Analyses?

Reviewer requests can be organized according to the nature of the work they imply.

Reviewer Request Possible Classification What Authors Must Determine
"Clarify how missing data were handled." Reporting clarification Whether the existing procedure was adequate and sufficiently described
"Recalculate the estimates using cluster-robust standard errors." Potential reanalysis Whether the dependence structure and proposed method justify the change
"Provide confidence intervals for the reported effects." Additional calculation or reporting Whether intervals already exist or can be computed from the original analysis
"Examine whether the findings differ by student year level." Potential subgroup analysis Whether the sample and design support meaningful subgroup inference
"Explain how the qualitative themes were developed." Analytical reporting clarification Whether the existing analysis is adequately documented
"Reconsider the coding framework in light of contradictory cases." Potential qualitative reanalysis Whether the concern requires revisiting the data and interpretations
"Collect additional data from another institution." New data collection Whether the request is feasible, ethical, and necessary for the study's claims

These classifications are provisional. The same wording may imply different work depending on the manuscript's existing analyses and the editor's instructions.

Clarification Is Not the Same as Reanalysis

A reviewer may request information that the authors already possess but did not report clearly.

For example, the manuscript may state that regression analysis was performed without describing how categorical predictors were coded.

The authors may be able to address the concern by expanding the Methods section and reporting the existing coding procedure.

No new model is necessarily required.

However, if the clarification reveals that the original analysis was inappropriate, reanalysis may become necessary.

The decision should follow the evidence rather than an AI-generated label.

Recalculation Is Different From a New Analytical Question

Some reviewer requests involve recomputing existing results under corrected assumptions or improved specifications.

For example, adjusting standard errors for clustering may change uncertainty estimates without changing the underlying research question.

Other requests introduce new questions, such as whether an intervention works differently across demographic groups.

These tasks have different methodological implications.

Recalculation may be necessary to correct an inferential problem. A new subgroup analysis may be exploratory and require additional caution concerning sample size, multiplicity, and interpretation.

AI should not treat both as equivalent forms of routine revision.

Can AI Identify Requests for Sensitivity Analysis?

AI may recognize terms such as robustness, sensitivity, alternative specification, or missing-data assumptions.

However, these terms do not specify a universally appropriate procedure.

A sensitivity analysis should examine how conclusions change under defensible alternative assumptions or analytical choices.

For example, authors might assess whether results remain similar under different missing-data assumptions or alternative operational definitions.

The relevant alternatives must be scientifically justified rather than selected merely because they produce favorable results.

Authors should determine which uncertainty or assumption the reviewer is asking them to examine before choosing an analysis.

New Analyses May Change the Scientific Conclusions

Additional analyses are not simply administrative tasks. They may change estimates, uncertainty intervals, interpretations, or the strength of the study's conclusions.

For example, accounting for classroom-level clustering may widen confidence intervals and alter how precisely an intervention effect is estimated.

A subgroup analysis may reveal heterogeneity, but it may also produce unstable estimates when subgroup sizes are small.

Authors should therefore update the relevant results, discussion, limitations, and abstract when justified analyses materially change the findings.

AI may help identify these downstream revision dependencies, but it should not determine the interpretation without independent verification.

When Is a Reviewer-Requested Analysis Inappropriate?

A reviewer may recommend a procedure that does not fit the research question, data structure, or methodological framework.

For example, requesting statistical power calculations for an interpretive qualitative study may be inappropriate.

Similarly, demanding a subgroup analysis may be problematic when the study lacks sufficient observations to estimate meaningful differences.

A recommendation to control for additional variables may also be inappropriate when those variables lie on the causal pathway or introduce other forms of bias.

Authors should evaluate the methodological justification rather than assume that every requested analysis will improve the research.

Can Authors Respectfully Decline a New Analysis?

Yes, provided the decision is scientifically defensible and consistent with the editor's requirements.

A reviewer may request an analysis that cannot be conducted because the necessary data were not collected or the procedure would not answer the study's research question.

Authors should explain the limitation or methodological rationale clearly.

For example, they might explain that the proposed subgroup comparison was not prespecified and that the available sample would produce imprecise estimates.

They may also revise the discussion to acknowledge the unanswered question without presenting unsupported new results.

The goal is to address the underlying concern rather than reject the recommendation dismissively.

Why AI Should Not Automatically Recommend More Statistical Tests

Generative AI may interpret a major revision as a reason to expand the analysis extensively.

However, additional tests can introduce multiplicity concerns, unstable estimates, and opportunities for selective reporting.

Exploratory analyses conducted after reviewer feedback may be useful, but they should be identified accurately and interpreted with appropriate caution.

Authors should avoid repeatedly testing alternative specifications until a desired result appears.

The distinction between confirmatory and exploratory analysis remains relevant even when additional work is requested during peer review.

Qualitative Reviewer Comments May Also Require Reanalysis

New analysis is not limited to statistics.

A reviewer may question whether a qualitative theme is adequately supported, whether contradictory cases were considered, or whether the interpretation reflects the study's theoretical orientation.

Addressing such concerns may require returning to transcripts, revisiting coding decisions, examining negative cases, or reconsidering theme development.

However, the appropriate response depends on the qualitative methodology.

For example, reflexive thematic analysis should not automatically be evaluated using coding-reliability procedures that conflict with its analytical assumptions.

AI-generated recommendations must therefore be assessed in relation to the study's methodological tradition.

New Data Collection Is Not the Same as New Analysis

Some reviewer comments request additional participants, experiments, interviews, or observations.

These requests extend beyond reanalyzing existing data.

New data collection may require additional ethics approval, participant recruitment, funding, or substantial changes to the study design.

It may also be impossible within the journal's revision period.

Authors should distinguish a request to analyze existing information differently from a request to generate new evidence.

If the requested work is infeasible or would constitute a substantially different study, a reasoned explanation and appropriately qualified conclusions may be more defensible.

How Should Authors Decide Whether an Analysis Is Feasible?

Feasibility should be evaluated before committing to the analysis in the response letter.

Relevant considerations include whether the required variables exist, whether the data are sufficiently complete, whether the analytical assumptions are defensible, and whether the research team has the necessary expertise.

For qualitative work, feasibility may concern access to the original transcripts, the adequacy of the data for the proposed interpretation, and consistency with the methodological approach.

Authors should also consider the journal's revision deadline and any ethical or institutional restrictions.

AI may help organize these considerations, but it cannot establish feasibility without accurate information about the actual research record.

Why Authors Should Document Analytical Changes

When additional analyses are conducted, the authors should preserve the relevant code, data-processing decisions, model specifications, and resulting outputs.

They should distinguish original analyses from those added during revision and explain whether the new work was confirmatory, exploratory, or conducted as a robustness check.

Where the results change, the manuscript and response letter should accurately describe those differences.

This documentation supports reproducibility and reduces the risk that an AI-assisted response exaggerates the extent or implications of the additional work.

AI Can Help Connect Analysis Requests to the Revision Plan

Once the authors have evaluated the scientific appropriateness of the requested work, AI may help organize the tasks and their dependencies.

For example, a new analysis may require updating a results table, revising the discussion, reconsidering the abstract, and preparing a response to the reviewer.

These related tasks can be tracked in a structured reviewer-comment revision action plan.

However, the plan should distinguish work that has been approved, completed, or rejected with justification.

AI-generated task lists should not be treated as evidence that analyses have been conducted.

Confidentiality and Disclosure Still Apply

Reviewer reports and manuscript materials may contain unpublished research information or confidential editorial content.

Authors should consult the journal's AI-use policies and the provider's data-handling arrangements before submitting such material to an external AI service.

Where AI assistance is permitted, the authors should use only authorized information and processing arrangements.

Disclosure requirements depend on the journal's current policy and the nature of the assistance.

The authors remain responsible for the scientific decisions, completed analyses, and accuracy of the final response letter.

04 · A Practical Example

Distinguishing Clarification From Reanalysis in an Educational Technology Study

Hypothetical Example

A Study of Online Learning Engagement and Academic Performance

A manuscript examines associations between students' learning management system engagement and academic performance.

The authors receive several reviewer comments concerning missing data, classroom clustering, subgroup differences, and causal interpretation.

Assume the journal permits the intended AI-assisted organization of reviewer comments under appropriate confidentiality safeguards.

Reviewer Comment Initial Classification Author Decision Needed
"Explain how missing observations were handled." Clarification Verify and describe the original procedure
"Account for classroom-level clustering." Potential reanalysis Assess the dependence structure and appropriate estimation method
"Examine whether effects differ by year level." Potential exploratory analysis Assess subgroup sizes, model assumptions, and interpretive value
"Avoid claiming that platform use caused higher grades." Interpretive revision Revise unsupported causal language
Step 1: Preserve the original reviewer wording

The authors retain the complete comments and use AI only to suggest provisional classifications of the requested work.

Step 2: Verify the classifications

The authors confirm that the missing-data comment may be resolved through reporting, while the clustering concern may require further statistical evaluation.

Step 3: Evaluate analytical feasibility

The statistical lead examines the data structure, available variables, and assumptions before deciding which analyses are justified.

Step 4: Conduct and document approved analyses

Any additional analyses are performed using appropriate software, independently checked, and recorded as part of the research workflow.

Step 5: Revise the manuscript and response letter

The authors update the relevant sections and describe only the analyses and revisions that were actually completed.

The example demonstrates that identifying a comment as a potential analysis request is only the beginning of the decision process.

The scientific question is whether additional analysis is necessary and appropriate to address the concern, not whether AI can generate a procedure that appears to satisfy the reviewer.

05 · What Researchers Often Get Wrong

Misconceptions About Reviewer-Requested Analyses

Misconception

Every Methodological Reviewer Comment Requires New Analysis

Some concerns can be addressed through clearer reporting or appropriately qualified interpretation. Reanalysis should follow a demonstrated scientific need.

Misconception

AI Can Decide Which Statistical Tests the Authors Must Conduct

AI may suggest procedures, but the authors must evaluate their appropriateness, assumptions, feasibility, and relevance to the research question.

Misconception

Additional Analyses Always Strengthen a Manuscript

Unnecessary analyses can introduce multiplicity, unstable estimates, and selective reporting risks. More analysis is not automatically better analysis.

Misconception

Authors Must Perform Every Analysis Requested by a Reviewer

Authors may provide reasoned disagreement when a request is inappropriate, infeasible, or inconsistent with the research design, subject to the editor's instructions.

Misconception

Qualitative Reviewer Comments Never Require Reanalysis

Qualitative revisions may require revisiting transcripts, coding, contradictory cases, or interpretations. The appropriate process depends on the methodology.

Misconception

A Planned Analysis Can Be Described as Completed in the Response Letter

Response letters must accurately distinguish proposed, completed, and unperformed work. AI-generated wording should not misrepresent revision status.

06 · What This Means for You

How to Decide Whether a Reviewer Comment Requires New Analysis

Authors should evaluate the underlying scientific concern before selecting an analytical response.

AI may help classify comments and organize work, but the final decision should reflect the research design, available evidence, and methodological implications.

A practical decision framework

If the reviewer asks how an existing procedure was performed
Check whether clarification of the original methods is sufficient before conducting new analysis.
If the reviewer identifies a plausible analytical error
Investigate the concern and conduct appropriate reanalysis when the original procedure is shown to be inadequate.
If the reviewer requests robustness or sensitivity checks
Determine which assumptions need examination and select scientifically justified alternatives.
If the reviewer proposes a new exploratory question
Assess whether the available data support meaningful analysis and clearly distinguish exploratory findings from original confirmatory claims.
If the requested analysis is inappropriate or infeasible
Provide a respectful methodological explanation and revise the manuscript's limitations or interpretation where necessary.

Document the Scientific Rationale for Every Additional Analysis

When an analysis is added during revision, the authors should record why it was conducted, how it was specified, and how its results affect the manuscript.

Any change to the analytical strategy should be transparent enough for readers and reviewers to understand its purpose.

Authors should also distinguish exploratory analyses added after reviewer feedback from analyses originally planned before examining the data.

Watch Out

Do not perform additional analyses simply because AI classified a reviewer comment as requiring them. The appropriate response depends on whether the analysis is scientifically justified, not on the apparent completeness of the generated revision plan.

The goal is to resolve legitimate methodological concerns with the least unnecessary alteration to the research, while ensuring that any new analysis is valid, reproducible, and accurately reported.

07 · A Quick Checklist

Checklist for Identifying Reviewer Requests That Require New Analyses

Before committing to a reviewer-requested analysis, check:
Preserve the original reviewer comment and editorial instructions.
Determine whether the concern involves clarification, recalculation, reanalysis, new data collection, or interpretation.
Verify any AI-generated classification against the actual reviewer wording.
Assess whether the requested procedure is appropriate to the research question and design.
Confirm that the necessary data, variables, and analytical resources are available.
Evaluate statistical assumptions, multiplicity, and the implications of exploratory analyses.
Consider whether a reasoned clarification or limitation statement would address the concern adequately.
Document the rationale, methods, and results of any additional analysis.
Update the manuscript and response letter to reflect the actual findings and revisions.
Follow journal policies concerning AI assistance, confidentiality, and disclosure.
08 · Frequently Asked Questions

Frequently Asked Questions About AI and Reviewer-Requested Analyses

Can ChatGPT identify which reviewer comments require new statistical analyses?

It can help flag comments that appear to request additional analyses, but authors must verify the classification and independently determine whether the proposed work is appropriate and necessary.

Does every request for methodological clarification require reanalysis?

No. Some concerns can be addressed by accurately describing existing procedures. Reanalysis may be necessary if the original method was inappropriate or the evidence is insufficient.

Can AI recommend sensitivity analyses in response to reviewers?

It may suggest possible sensitivity checks, but authors should select analyses based on the assumptions being examined and verify that the procedures are methodologically justified.

Must authors conduct every new analysis requested by reviewers?

Not necessarily. Authors may respectfully explain why a requested analysis is inappropriate, infeasible, or unnecessary, while addressing the underlying concern and following the editor's instructions.

Can reviewer comments require new qualitative analysis?

Yes. Some comments may warrant revisiting transcripts, coding decisions, contradictory cases, or interpretations, depending on the qualitative methodology and the concern raised.

Should additional analyses be labeled exploratory?

When analyses were developed after examining the data or in response to reviewer suggestions, authors should accurately describe their timing and inferential purpose. Exploratory work should not be presented misleadingly as prespecified confirmation.

Can AI decide whether the available sample is adequate for subgroup analysis?

AI may explain relevant considerations, but adequacy depends on the study design, subgroup sizes, expected precision, and intended inference. Authors should evaluate these factors using appropriate methods.

Can AI draft the response after the new analysis is completed?

Yes, where permitted. Authors should provide verified revision records and ensure that the drafted response accurately reports the analysis, results, and manuscript changes.

09 · The Bottom Line

Identify the Analytical Need Before Choosing the Analysis

The Bottom Line

Generative AI can help identify reviewer comments that may require additional analyses, but it cannot independently determine whether those analyses are scientifically necessary, appropriate, or feasible.

Authors should distinguish clarification from reanalysis, evaluate each request against the research design and available evidence, and document any new work accurately. The objective is to address legitimate scientific concerns, not to expand the analysis simply because a reviewer or AI system suggested doing more.

10 · Sources and Further Reading

Authoritative Sources on Statistical Reanalysis and Manuscript Revision

11 · Cite this Guide

How to Cite This Guide

This guide is intended to be read, shared, and used in research, teaching, and academic work. If you draw on its ideas, explanations, or other content, please acknowledge the source by citing the guide. Doing so gives appropriate credit and helps your readers locate the original resource.

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